| Date | Location | Result | |
| 12/03/21 | Lexington, Ky. | Kentucky 3, Southeast Missouri 0 (25-15,25-14,25-19) | Box score |
| 11-20-21 | Cape Girardeau, Mo. | Southeast Missouri 3, Morehead State 2 (25-22,25-23,19-25,15-25,15-13) | Box score |
| 11-19-21 | Cape Girardeau, Mo. | Southeast Missouri 3, Murray State 1 (22-25,25-18,25-15,26-24) | Box score |
| 11-18-21 | Cape Girardeau, Mo. | Southeast Missouri 3, Eastern Illinois 0 (25-13,25-15,25-18) | Box score |
| 11/13/21 | Cape Girardeau, Mo. | Southeast Missouri 3, Morehead State 0 (25-23,25-15,25-18) | Box score |
| 11/12/21 | Cape Girardeau, Mo. | Southeast Missouri 3, Morehead State 0 (25-22,25-23,25-23) | Box score |
| 11/06/21 | Murray, Ky. | Murray State 3, Southeast Missouri 0 (25-22,25-21,25-21) | Box score |
| 11/05/21 | Murray, Ky. | Southeast Missouri 3, Murray State 1 (27-25,25-13,22-25,25-17) | Box score |
| 10/29/21 | Cape Girardeau, Mo. | Southeast Missouri 3, Austin Peay 0 (25-9,25-18,25-19) | Box score |
| 10/28/21 | Cape Girardeau, Mo. | Southeast Missouri 3, Austin Peay 2 (33-35,25-22,25-22,23-25,15-9) | Box score |
| 10/23/21 | Cookeville, Tenn. | Tennessee Tech 3, Southeast Missouri 0 (25-23,25-20,25-21) | Box score |
| 10/22/21 | Cookeville, Tenn. | Southeast Missouri 3, Tennessee Tech 1 (25-23,26-24,20-25,25-16) | Box score |
| 10/16/21 | Cape Girardeau, Mo. | Southeast Missouri 3, SIUE 0 (25-12,25-17,26-24) | Box score |
| 10/15/21 | Cape Girardeau, Mo. | Southeast Missouri 3, SIUE 0 (25-19,25-19,25-17) | Box score |
| 10/12/21 | Martin, Tenn. | Southeast Missouri 3, UT Martin 1 (16-25,25-20,25-18,25-21) | Box score |
| 10/09/21 | Charleston, Ill. | Southeast Missouri 3, Eastern Illinois 0 (25-23,25-22,25-18) | Box score |
| 10/08/21 | Charleston, Ill. | Southeast Missouri 3, Eastern Illinois 0 (25-23,25-18,27-25) | Box score |
| 10/2/2021 | Cape Girardeau, Mo. | Southeast Missouri 3, Belmont 0 (25-10,25-9,25-6) | Box score |
| 10/1/2021 | Cape Girardeau, Mo. | Southeast Missouri 3, Belmont 0 (25-20,25-19,25-19) | Box score |
| 9/29/2021 | Cape Girardeau, Mo. | UT Martin 3, Southeast Missouri 2 (25-23,25-20,22-25,23-25,15-13) | Box score |
| 09/25/21 | Nashville, Tenn. | Tennessee St. 3, Southeast Missouri 1 (25-22,25-17,17-25,25-22) | Box score |
| 09/24/21 | Nashville, Tenn. | Southeast Missouri 3, Tennessee St. 2 (20-25,25-17,25-11,23-25,15-10) | Box score |
| 9/18/2021 | Cape Girardeau, Mo. | Southeast Missouri 3, Central Arkansas 0 (25-13,25-12,25-18) | Box score |
| 9/17/2021 | Cape Girardeau, Mo. | Southeast Missouri 3, SIU 0 (25-17,25-18,25-11) | Box score |
| 09/17/2021 | Cape Girardeau, Mo. | Southeast Missouri 3, Tulsa 1 (25-21,16-25,25-17,25-9) | Box score |
| 9/11/2021 | Cape Girardeau, Mo. | Arkansas State 3, Southeast Missouri 2 (25-20,16-25,25-23,24-26,15-13) | Box score |
| 9/10/2021 | Cape Girardeau, Mo. | Southeast Missouri 3, Memphis 2 (25-21,25-20,23-25,24-26,15-13) | Box score |
| 9/10/2021 | Cape Girardeau, Mo. | Southeast Missouri 3, Marshall 1 (18-25,25-13,25-18,25-15) | Box score |
| 09/04/21 | Kalamazoo, Mich. | Indiana 3, Southeast Missouri 2 (19-25,25-23,14-25,25-17,15-9) | Box score |
| 09/03/21 | Kalamazoo, Mich. | Southeast Missouri 3, Purdue Fort Wayne 0 (25-14,25-22,25-18) | Box score |
| 09/03/21 | Kalamazoo, Mich. | Western Michigan 3, Southeast Missouri 2 (19-25,25-19,21-25,25-17,15-12) | Box score |
| 08-28-21 | Peoria, Ill. | Southeast Missouri 3, Central Michigan 0 (26-24,25-22,25-22) | Box score |
| 08-28-21 | Peoria, Ill. | Southeast Missouri 3, Bradley 1 (25-18,25-17,24-26,25-14) | Box score |
| 08-27-21 | Peoria, Ill. | Southeast Missouri 3, DePaul 1 (28-26,19-25,25-22,25-23) | Box score |