| Date | Location | Result | |
| 11/05/21 | Martin, Tenn. | SIUE 3, Southeast Missouri 0 | Box score |
| 10/31/21 | Nashville, Tenn. | Southeast Missouri 2, Belmont 1 (OT) | Box score |
| 10/29/21 | Nashville, Tenn. | Southeast Missouri 1, Morehead State 0 | Box score |
| 10/24/21 | Cape Girardeau, Mo. | Tennessee Tech 0, Southeast Missouri 0 (2OT) | Box score |
| 10/21/21 | Edwardsville, Ill., | SIUE 3, Southeast Missouri 1 | Box score |
| 10/17/21 | Morehead, Ky. | Southeast Missouri 0, Morehead State 0 (2OT) | Box score |
| 10/14/2021 | Cape Girardeau, Mo. | Southeast Missouri 1, Eastern Illinois 0 | Box score |
| 10/10/21 | Clarksville, Tenn. | Southeast Missouri 1, Austin Peay 0 | Box score |
| 10/3/2021 | Cape Girardeau, Mo. | UT Martin 4, Southeast Missouri 1 | Box score |
| 09/30/21 | Murray, Ky. | Murray St. 2, Southeast Missouri 1 | Box score |
| 9/26/2021 | Cape Girardeau, Mo. | BELMONT 1, Southeast Missouri 0 (2OT) | Box score |
| 9/19/2021 | Cape Girardeau, Mo. | Southeast Missouri 1, Missouri State 0 | Box score |
| 09/12/21 | Iowa City, Iowa | Iowa 2, Southeast Missouri 0 | Box score |
| 09/05/21 | Bloomington, Ind. | Indiana 6, Southeast Missouri 0 | Box score |
| 09/02/21 | Evansville, Ind. | Evansville 1, Southeast Missouri 0 | Box score |
| 08/29/21 | Starkville, Miss. | Mississippi State 1, Southeast Missouri 0 | Box score |
| 08/26/2021 | Cape Girardeau, Mo. | Southeast Missouri 1, Missouri-St. Louis 0 | Box score |
| 08/22/2021 | Cape Girardeau, Mo. | Southeast Missouri 4, Maryville 1 | Box score |
| 08/19/21 | Memphis, Tenn. | Memphis 4, Southeast Missouri 0 | Box score |