| Date | Location | Result | |
| 02/26/22 | Cape Girardeau, MO | Murray St. 86, Southeast Mo. St. 54 | Box score |
| 02/24/22 | Cape Girardeau, Mo. | UT Martin 70, Southeast Mo. St. 49 | Box score |
| 2/19/22 | Morehead, Ky. | Southeast Mo. St. 70, Morehead State 62 | Box score |
| 02/17/22 | Cookeville, TN | Tennessee Tech 65, Southeast Mo. St. 55 | Box score |
| 02/12/22 | Cape Girardeau, Mo. | Belmont 70, Southeast Mo. St. 67 | Box score |
| 02/10/22 | Clarksville, Tenn. | Austin Peay 79, Southeast Mo. St. 38 | Box score |
| 02/05/22 | Cape Girardeau, Mo. | Eastern Ill. 72, Southeast Mo. St. 53 | Box score |
| 02/03/22 | Martin, Tenn. | UT Martin 70, Southeast Mo. St. 66 | Box score |
| 01/29/22 | Cape Girardeau, MO | SIUE 69, Southeast Mo. St. 61 | Box score |
| 01/27/22 | Cape Girardeau, MO | Southeast Mo. St. 60, Morehead St. 53 | Box score |
| 01/22/22 | Charleston, Ill. | Eastern Ill. 68, Southeast Mo. St. 44 | Box score |
| 01/20/22 | Show Me Center -- Cape Girardeau, Mo. | Tennessee St. 68, Southeast Missouri 53 | Box score |
| 01/15/22 | Edwardsville, Ill. | SIUE 73, Southeast Mo. St. 66 | Box score |
| 01/13/22 | Show Me Center -- Cape Girardeau, Mo. | Tennessee Tech 75, Southeast Missouri 58 | Box score |
| 01/08/22 | Nashville, Tenn. | Tennessee St. 83, Southeast Mo. St. 64 | Box score |
| 01/06/22 | Nashville, Tenn. | Belmont 85, Southeast Mo. St. 65 | Box score |
| 01/01/22 | Show Me Center -- Cape Girardeau, Mo. | Austin Peay 72, Souheast Missouri 62 | Box score |
| 12/30/21 | Murray, Ky. | Murray St. 82, Southeast Mo. St. 58 | Box score |
| 12/19/21 | Cincinnati, Ohio | Xavier 65, Southeast Mo. St. 58 | Box score |
| 12/09/21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 68, Purdue Fort Wayne 51 | Box score |
| 12/05/21 | Show Me Center -- Cape Girardeau, Mo. | Souheast Missouri 95, Harris-Stowe 57 | Box score |
| 12/03/21 | Show Me Center -- Cape Girardeau, Mo. | Saint Louis 83, Souheast Missouri 54 | Box score |
| 11/30/21 | Show Me Center -- Cape Girardeau, Mo. | Southern Illinois 78, Southeast Missouri 61 | Box score |
| 11/27/21 | Hattiesburg, Miss. | Ark.-Pine Bluff 81, Southeast Mo. St. 63 | Box score |
| 11/26/21 | Hattiesburg, Miss. | Southeast Mo. St. 82, Mississippi Val. 76 | Box score |
| 11/22/21 | Show Me Center -- Cape Girardeau, Mo. | Arkansas State 73, Souheast Missouri 65 | Box score |
| 11/17/21 | Austin, Texas | Texas 88, Southeast Mo. St. 47 | Box score |
| 11/15/21 | Nacogdoches, Texas | Stephen F. Austin 83, Southeast Mo. St. 59 | Box score |
| 11-09-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 68, Health Sciences & Pharmacy 45 | Box score |