| Date | Location | Result | |
| 05-13-22 | Oxford, Ala. | Belmont 3, Southeast Missouri 2 | Box score |
| 05-13-22 | Oxford, Ala. | Southeast Missouri 10, UT Martin 8 | Box score |
| 05-12-22 | Oxford, Ala. | Southeast Missouri 6, Tennessee Tech 5 | Box score |
| 05-12-22 | Oxford, Ala. | Murray State 3, Southeast Missouri 1 | Box score |
| 05-11-22 | Oxford, Ala. | Southeast Missouri 9, SIUE 1 | Box score |
| 05-08-22 | Cape Girardeau, Mo. | Southeast Missouri 9, Belmont 2 | Box score |
| 05-08-22 | Cape Girardeau, Mo. | Southeast Missouri 5, Belmont 3 | Box score |
| 05-07-22 | Cape Girardeau, Mo. | Southeast Missouri 3, Belmont 1 | Box score |
| 05-01-22 | Edwardsville, Ill. | SIUE 3, Southeast Missouri 2 | Box score |
| 05-01-22 | Edwardsville, Ill. | SIUE 9, Southeast Missouri 1 | Box score |
| 04-30-22 | Edwardsville, Ill. | SIUE 7, Southeast Missouri 4 | Box score |
| 04-27-22 | Cape Girardeau, Mo. | Southeast Missouri 5, UT Martin 4 | Box score |
| 04-27-22 | Cape Girardeau, Mo. | Southeast Missouri 4, UT Martin 3 | Box score |
| 04-24-22 | Murray, Ky. | Southeast Missouri 5, Murray State 2 | Box score |
| 04-24-22 | Murray, Ky. | Murray State 4, Southeast Missouri 0 | Box score |
| 04-23-22 | Murray, Ky. | Murray State 1, Southeast Missouri 0 | Box score |
| 04-16-22 | Clarksville, Tenn. | Austin Peay 3, Southeast Missouri 0 | Box score |
| 04-16-22 | Clarksville, Tenn. | Austin Peay 3, Southeast Missouri 1 | Box score |
| 04-15-22 | Clarksville, Tenn. | Southeast Missouri 3, Austin Peay 2 | Box score |
| 04-12-22 | Fayetteville, Ark. | Arkansas 14, Southeast Missouri 0 | Box score |
| 04-12-22 | Fayetteville, Ark. | Arkansas 9, Southeast Missouri 1 | Box score |
| 04-10-22 | Cape Girardeau, Mo. | Southeast Missouri 8, Eastern Illinois 0 | Box score |
| 04-10-22 | Cape Girardeau, Mo. | Southeast Missouri 7, Eastern Illinois 6 | Box score |
| 04-09-22 | Cape Girardeau, Mo. | Southeast Missouri 13, Eastern Illinois 1 | Box score |
| 04-03-22 | Cape Girardeau, Mo. | Southeast Missouri 8, Morehead State 0 | Box score |
| 04-03-22 | Cape Girardeau, Mo. | Southeast Missouri 12, Morehead State 2 | Box score |
| 04-02-22 | Cape Girardeau, Mo. | Southeast Missouri 4, Morehead State 0 | Box score |
| 03-27-22 | Cookeville, Tenn. | Tennessee Tech 2, Southeast Missouri 0 | Box score |
| 03-26-22 | Cookeville, Tenn. | Tennessee Tech 5, Southeast Missouri 4 | Box score |
| 03-26-22 | Cookeville, Tenn. | Tennessee Tech 5, Southeast Missouri 3 | Box score |
| 03-20-22 | Cape Girardeau, Mo. | Southeast Missouri 11, Tennessee State 3 | Box score |
| 03-20-22 | Cape Girardeau, Mo. | Southeast Missouri 6, Tennessee State 0 | Box score |
| 03-19-22 | Cape Girardeau, Mo. | Southeast Missouri 9, Tennessee State 1 | Box score |
| 03-15-22 | Kansas City, MO | Southeast Missouri 4, Iowa 3 | Box score |
| 03-15-22 | Kansas City, MO | Southeast Missouri 7, Kansas City Roos 1 | Box score |
| 03-14-22 | Lawrence, Kan. | Kansas 8, Southeast Missouri 0 | Box score |
| 03-13-22 | Lawrence, Kan. | Wichita St 14, Southeast Missouri 0 | Box score |
| 03-13-22 | Lawrence, Kan. | Missouri State 10, Southeast Missouri 8 | Box score |
| 03-06-22 | Nashville, Tenn. | Lipscomb 2, Southeast Missouri 0 | Box score |
| 03-05-22 | Nashville, Tenn. | Southeast Missouri 10, Dayton 6 | Box score |
| 03-05-22 | Nashville, Tenn. | Southeast Missouri 3, Charleston 2 | Box score |
| 03-04-22 | Nashville, Tenn. | Southeast Missouri 7, Lipscomb 1 | Box score |
| 03-04-22 | Nashville, Tenn. | Southeast Missouri 5, Charleston 4 | Box score |
| 03-02-22 | Oxford, Miss. | Ole Miss 7, Southeast Missouri 4 | Box score |
| 02-20-22 | Bowling Green, Ky. | WKU 5, Southeast Missouri 4 | Box score |
| 02-19-22 | Bowling Green, Ky. | Southeast Missouri 12, Central Michigan 4 | Box score |
| 02-19-22 | Bowling Green, Ky. | WKU 4, Southeast Missouri 3 | Box score |
| 02-18-22 | Bowling Green, Ky. | Bellarmine 4, Southeast Missouri 3 | Box score |
| 02-18-22 | Bowling Green, Ky. | Southeast Missouri 6, Central Michigan 0 | Box score |
| 02-13-22 | Hammond, La. | Southeast Missouri 5, Nicholls 2 | Box score |
| 02-12-22 | Hammond, La. | Southeastern 6, Southeast Missouri 5 | Box score |
| 02-12-22 | Hammond, La. | Southeast Missouri 13, Nicholls 5 | Box score |
| 02-11-22 | Hammond, La. | Southeastern 6, Southeast Missouri 2 | Box score |
| 02-11-22 | Hammond, La. | Southeast Missouri 13, Alabama A&M 0 | Box score |