| Date | Location | Result | |
| 05-15-21 | Oxford, Ala. | Eastern Kentucky 5, Southeast Missouri 4 | Box score |
| 05-14-21 | Oxford, Ala. | Southeast Missouri 4, Jacksonville State 3 | Box score |
| 05-14-21 | Oxford, Ala. | Eastern Kentucky 2, Southeast Missouri 1 | Box score |
| 05-13-21 | Oxford, Ala. | Southeast Missouri 11, Jacksonville State 2 | Box score |
| 05-09-21 | Jacksonville, Ala. | Jacksonville State 4, Southeast Missouri 3 | Box score |
| 05-08-21 | Jacksonville, Ala. | Southeast Missouri 3, Jacksonville State 2 | Box score |
| 05-08-21 | Jacksonville, Ala. | Southeast Missouri 10, Jacksonville State 5 | Box score |
| 05-05-21 | Martin, Tenn. | Southeast Missouri 8, UT Martin 0 | Box score |
| 05-05-21 | Martin, Tenn. | Southeast Missouri 3, UT Martin 1 | Box score |
| 05-02-21 | Cape Girardeau, Mo. | Southeast Missouri 3, Murray State 2 | Box score |
| 05-01-21 | Cape Girardeau, Mo. | Southeast Missouri 7, Murray State 5 | Box score |
| 05-01-21 | Cape Girardeau, Mo. | Southeast Missouri 1, Murray State 0 | Box score |
| 04-18-21 | Cape Girardeau, Mo. | Eastern Kentucky 4, Southeast Missouri 1 | Box score |
| 04-17-21 | Cape Girardeau, Mo. | Eastern Kentucky 6, Southeast Missouri 2 | Box score |
| 04-17-21 | Cape Girardeau, Mo. | Southeast Missouri 8, Eastern Kentucky 0 | Box score |
| 04-14-21 | Cape Girardeau, Mo. | Southeast Missouri 2, Saint Louis 0 | Box score |
| 04-11-21 | Edwardsville, Ill. | SIUE 6, Southeast Mo. St. 5 | Box score |
| 04-11-21 | Edwardsville, Ill. | Southeast Mo. St. 4, SIUE 2 | Box score |
| 04-10-21 | Edwardsville, Ill. | Southeast Mo. St. 11, SIUE 2 | Box score |
| 04-03-21 | Cape Girardeau, Mo. | Eastern Illinois 5, Southeast Missouri 1 | Box score |
| 04-03-21 | Cape Girardeau, Mo. | Southeast Missouri 3, Eastern Illinois 0 | Box score |
| 04-02-21 | Cape Girardeau, Mo. | Southeast Missouri 7, Eastern Illinois 0 | Box score |
| 03-31-21 | Cape Girardeau, Mo. | Southeast Missouri 5, Southern Illinois 0 | Box score |
| 03-27-21 | Cape Girardeau, Mo. | Southeast Missouri 9, Morehead State 1 | Box score |
| 03-27-21 | Cape Girardeau, Mo. | Southeast Missouri 10, Morehead State 0 | Box score |
| 03-26-21 | Cape Girardeau, Mo. | Southeast Missouri 8, Morehead State 0 | Box score |
| 03-24-21 | St. Louis, Mo. | SE Missouri 6, Saint Louis 1 | Box score |
| 03-21-21 | Nashville, Tenn. | Southeast Mo State 8, Belmont Bruins 4 | Box score |
| 03-20-21 | Nashville, Tenn. | Southeast Mo State 6, Belmont Bruins 0 | Box score |
| 03-20-21 | Nashville, Tenn, | Southeast Mo State 8, Belmont Bruins 2 | Box score |
| 03-16-21 | Carbondale, Ill. | Southern Illinois 6, Southeast Mo. State 2 | Box score |
| 03-13-21 | Cookeville, Tenn. | Southeast Missouri 8, Tennessee Tech 4 | Box score |
| 03-12-21 | Cookeville, Tenn. | Southeast Missouri 4, Tennessee Tech 1 | Box score |
| 03-12-21 | Cookeville, Tenn. | Southeast Missouri 7, Tennessee Tech 0 | Box score |
| 03-06-21 | Cape Girardeau, Mo. | Southeast Missouri 8, Austin Peay 0 | Box score |
| 03-06-21 | Cape Girardeau, Mo. | Austin Peay 4, Southeast Missouri 3 | Box score |
| 03-05-21 | Cape Girardeau, Mo. | Southeast Missouri 6, Austin Peay 5 | Box score |
| 02-28-21 | Fayetteville, Ark. | Texas Tech 7, Southeast Missouri 1 | Box score |
| 02-27-21 | Fayetteville, Ark. | Arkansas 6, Southeast Missouri 3 | Box score |
| 02-27-21 | Fayetteville, Ark. | Southeast Missouri 5, Texas Tech 3 | Box score |
| 02-26-21 | Fayetteville, Ark. | Arkansas 9, Southeast Missouri 3 | Box score |
| 02-26-21 | Fayetteville, Ark. | Southeast Missouri 6, North Dakota State 2 | Box score |
| 02-20-21 | Knoxville, Tenn. | Tennessee 5, SE Missouri State 3 | Box score |
| 02-20-21 | Knoxville, Tenn. | Tennessee 7, SE Missouri State 0 | Box score |
| 02-14-21 | Auburn, Ala. | Auburn 3, Southeast Missouri 1 | Box score |
| 02-13-21 | Auburn, Ala. | Auburn 5, Southeast Missouri 1 | Box score |
| 02-13-21 | Auburn, Ala. | Auburn 8, Southeast Missouri 0 | Box score |