| Date | Location | Result | |
| 03-03-21 | Ford Center -- Evansville, Ind. | Morehead St. 61, Southeast Mo. St. 54 | Box score |
| 02-27-21 | First Community Arena - Edwardsville, IL | Southeast Mo. St. 69, SIUE 63 | Box score |
| 02-25-21 | Lantz Arena -- Charleston, Ill. | Southeast Mo. St. 94, Eastern Ill. 88 | Box score |
| 02-22-21 | Show Me Center -- Cape Girardeau, Mo. | Eastern Kentucky 87, Southeast Missouri 65 | Box score |
| 02-20-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 94, Eastern Kentucky 72 | Box score |
| 02-16-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 86, Austin Peay 81 (OT) | Box score |
| 02-13-21 | Dunn Center -- Clarksville, Tenn. | Austin Peay 78, Southeast Mo. St. 63 | Box score |
| 02-12-21 | CFSB Center -- Murray, Ky. | Murray St. 80, Southeast Mo. St. 60 | Box score |
| 02-06-21 | Show Me Center -- Cape Girardeau, Mo. | Jacksonville State 66, Southeast Missouri 54 | Box score |
| 02-04-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 68, Tennessee Tech 64 | Box score |
| 02-01-21 | Show Me Center -- Cape Girardeau, Mo. | Murray State 77, Southeast Missouri 60 | Box score |
| 01-30-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 75, Eastern Illinois 44 | Box score |
| 01-28-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 64, SIUE 62 | Box score |
| 01-26-21 | Elam Center -- Martin, Tenn. | UT Martin 69, Southeast Mo. St. 66 | Box score |
| 01-21-21 | Johnson Arena -- Morehead, Ky. | Morehead State 76, Southeast Missouri 65 | Box score |
| 01-19-21 | Gentry Center -- Nashville, Tenn. | Southeast Mo. St. 63, Tennessee St. 59 | Box score |
| 01-16-21 | Show Me Center -- Cape Girardeau, Mo. | Morehead State 64, Southeast Missouri 50 | Box score |
| 01-07-21 | Curb Event Center -- Nashville, Tenn. | Belmont 77, Southeast Mo. St. 66 | Box score |
| 01-02-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 83, Tennessee State 79 (2OT) | Box score |
| 12-30-20 | Eblen Center -- Cookeville, Tenn. | Tennessee Tech 72, Southeast Mo. St. 63 | Box score |
| 12-22-20 | Hulman Center -- Terre Haute, Ind. | Indiana St. 72, Southeast Mo. St. 66 | Box score |
| 12-18-20 | Show Me Center -- Cape Girardeau, Mo. | UT Martin 69, Southeast Missouri 67 | Box score |
| 12-15-20 | Ford Center -- Evansville, Ind. | Evansville 66, Southeast Mo. St. 63 (OT) | Box score |
| 12-09-20 | Allen Arena -- Nashville, Tenn. | Lipscomb 80, SEMO 74 (OT) | Box score |
| 12-07-20 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 82, Lipscomb 77 | Box score |
| 12-02-20 | Show Me Center -- Cape Girardeau, Mo. | Southern Illinois 87, Southeast Missouri 79 (OT) | Box score |
| 11-28-20 | Mabee Fieldhouse -- Kansas City, Mo. | Southeast Mo. St. 71, Kansas City 66 | Box score |