| Date | Location | Result | |
| 03-08-25 | Ford Center -- Evansville, Ind. | SIUE 69, Southeast Mo. St. 48 | Box score |
| 03-07-25 | Ford Center -- Evansville, Ind. | Southeast Mo. St. 78, Little Rock 59 | Box score |
| 03-01-25 | Groniger Arena -- Charleston, Ill. | Eastern Ill. 73, Southeast Mo. St. 58 | Box score |
| 02-27-25 | First Comm. Arena -- Edwardsville, Ill. | Southeast Mo. St. 83, SIUE 68 | Box score |
| 02-22-25 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 74, Lindenwood 58 | Box score |
| 02-20-25 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 87, Western Ill. 66 | Box score |
| 02-15-25 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 83, Tennessee Tech 69 | Box score |
| 02-11-25 | Jack Stephens Center -- Little Rock, Ark | Southeast Mo. St. 57, Little Rock 45 | Box score |
| 02-08-25 | Liberty Arena -- Evansville, Ind. | Southeast Mo. St. 79, Southern Ind. 74 | Box score |
| 02-06-25 | Johnson Arena -- Morehead, Ky. | Southeast Mo. St. 80, Morehead St. 51 | Box score |
| 02-01-25 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 89, Tennessee St. 87 (OT) | Box score |
| 01-30-25 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 90, UT Martin 79 | Box score |
| 01-25-25 | Western Hall -- Macomb, Ill. | Southeast Mo. St. 72, Western Ill. 51 | Box score |
| 01-23-25 | Hyland Arena -- St. Charles, Mo. | Lindenwood 72, Southeast Mo. St. 68 | Box score |
| 01-16-25 | Eblen Center -- Cookeville, Tenn. | Southeast Mo. St. 77, Tennessee Tech 70 | Box score |
| 01-14-25 | Show Me Center -- Cape Girardeau, Mo. | Little Rock 73, Southeast Mo. St. 71 | Box score |
| 01-11-25 | Show Me Center -- Cape Girardeau, Mo. | Morehead St. 67, Southeast Mo. St. 56 | Box score |
| 01-09-25 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 77, Southern Ind. 66 | Box score |
| 01-04-25 | Elam Center -- Martin, Tenn. | UT Martin 66, Southeast Mo. St. 63 | Box score |
| 01-02-25 | Gentry Center -- Nashville, Tenn. | Southeast Mo. St. 67, Tennessee St. 65 | Box score |
| 12-29-24 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 88, Westminster (MO) 39 | Box score |
| 12-21-24 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 80, SIUE 64 | Box score |
| 12-19-24 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 79, Eastern Ill. 72 | Box score |
| 12-15-24 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 93, St. Mary-Woods 56 | Box score |
| 12-08-24 | CFSB Center -- Murray, Ky. | Murray St. 73, Southeast Mo. St. 53 | Box score |
| 12-05-24 | Allen Arena -- Nashville, Tenn. | Lipscomb 78, Southeast Mo. St. 60 | Box score |
| 11-30-24 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 80, Kansas City 59 | Box score |
| 11-22-24 | Farris Center -- Conway, Ark. | UNC Asheville 72, Southeast Mo. St. 64 | Box score |
| 11-21-24 | Farris Center -- Conway, Ark. | Southeast Mo. St. 77, Central Ark. 73 (OT) | Box score |
| 11-17-24 | Show Me Center -- Cape Girardeau, Mo. | Chattanooga 87, Southeast Mo. St. 82 | Box score |
| 11-13-24 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 93, Crowley's Ridge 38 | Box score |
| 11-10-24 | Memorial Gymnasium -- Nashville, Tenn. | Vanderbilt 85, Southeast Mo. St. 76 | Box score |
| 11-04-24 | Carver Arena -- Peoria, Ill. | Bradley 88, Southeast Mo. St. 60 | Box score |