| Date | Location | Result | |
| 03-04-22 | Ford Center -- Evansville, Ind. | Murray St. 88, Southeast Mo. St. 74 | Box score |
| 03-03-22 | Ford Center -- Evansville, Ind. | Southeast Mo. St. 79, Tennessee St. 55 | Box score |
| 02-26-22 | Show Me Center -- Cape Girardeau, Mo. | Murray St. 70, Southeast Mo. St. 68 | Box score |
| 02-24-22 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 76, UT Martin 69 | Box score |
| 02-19-22 | Johnson Arena -- Morehead, Ky. | Southeast Mo. St. 92, Morehead State 84 | Box score |
| 02-17-22 | Eblen Center -- Cookeville, Tenn. | Tennessee Tech 98, Southeast Mo. St. 94 | Box score |
| 02-12-22 | Show Me Center -- Cape Girardeau, Mo. | Belmont 81, Southeast Mo. St. 72 | Box score |
| 02-10-22 | Dunn Center -- Clarksville, Tenn. | Austin Peay 74, Southeast Mo. St. 66 | Box score |
| 02-07-22 | First Comm. Arena -- Edwardsville, Ill. | Southeast Mo. St. 76, SIUE 47 | Box score |
| 02-05-22 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 63, Eastern Ill. 56 | Box score |
| 02-03-22 | Elam Center -- Martin, Tenn. | UT Martin 84, Southeast Mo. St. 63 | Box score |
| 01-29-22 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 85, SIUE 77 | Box score |
| 01-27-22 | Show Me Center -- Cape Girardeau, Mo. | Morehead St. 74, Southeast Mo. St. 73 (OT) | Box score |
| 01-22-22 | Lantz Arena -- Charleston, Ill. | Southeast Mo. St. 87, Eastern Ill. 58 | Box score |
| 01-20-22 | Show Me Center -- Cape Girardeau, Mo. | Southeast Mo. St. 85, Tennessee St. 63 | Box score |
| 01-08-22 | Gentry Center -- Nashville, Tenn. | Tennessee St. 95, Southeast Mo. St. 84 | Box score |
| 01-06-22 | Curb Event Center -- Nashville, Tenn. | Belmont 102, Southeast Mo. St. 62 | Box score |
| 01-01-22 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 98, Austin Peay 79 | Box score |
| 12-30-21 | CFSB Center -- Murray, Ky. | Murray St. 106, Southeast Mo. St. 81 | Box score |
| 12-21-21 | CBU Events Center -- Riverside, Calif. | California Baptist 84, Southeast Mo. St. 68 | Box score |
| 12-18-21 | Firestone Fieldhouse -- Malibu, Calif. | Pepperdine 83, Southeast Mo. St. 77 | Box score |
| 12-15-21 | Banterra Center -- Carbondale, Ill. | Southern Ill. 80, Southeast Mo. St. 55 | Box score |
| 12-11-21 | Memorial Coliseum -- Fort Wayne, Ind. | Purdue Fort Wayne 78, Southeast Mo. St. 65 | Box score |
| 12-08-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 75, Evansville 73 | Box score |
| 12-04-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 76, Webster University 64 | Box score |
| 11-28-21 | McDermott Center -- San Antonio, Texas | Montana St. 75, Southeast Mo. St. 68 | Box score |
| 11-27-21 | McDermott Center -- San Antonio, Texas | Portland 74, Southeast Mo. St. 68 | Box score |
| 11-26-21 | McDermott Center -- San Antonio, Texas | Southeast Mo. St. 79, Incarnate Word 76 | Box score |
| 11-22-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 71, Missouri Baptist 63 | Box score |
| 11-19-21 | Show Me Center -- Cape Girardeau, Mo. | Arkansas State 72, Southeast Missouri 60 | Box score |
| 11-13-21 | Show Me Center -- Cape Girardeau, Mo. | Youngstown State 97, Southeast Missouri 79 | Box score |
| 11-09-21 | JQH Arena -- Springfield, Mo. | Southeast Mo. St. 99, Missouri St. 94 | Box score |