| Date | Location | Result | |
| 11-26-22 | Missoula, Mont. | Montana 34, Southeast Missouri 24 | Box score |
| 11-19-22 | Cape Girardeau, Mo. | Southeast Missouri 52, Murray St. 22 | Box score |
| 11-12-22 | Charleston, Ill. | Southeast Missouri 31, Eastern Illinois 7 | Box score |
| 11-05-22 | Nashville, Tenn. | Southeast Missouri 42, Tennessee St. 0 | Box score |
| 10-29-22 | Cape Girardeau, Mo. | Eastern Ky. 28, Southeast Missouri 23 | Box score |
| 10-22-22 | Natchitoches, La. | Southeast Missouri 51, Northwestern St. 16 | Box score |
| 10-08-22 | Cape Girardeau, Mo. | Southeast Missouri 34, Tennessee Tech 20 | Box score |
| 10-01-22 | St. Charles, Mo. | Southeast Missouri 49, Lindenwood 28 | Box score |
| 09-24-22 | Cape Girardeau, Mo. | Southeast Missouri 35, Central Arkansas 27 | Box score |
| 09-17-22 | Cape Girardeau, Mo. | Southeast Missouri 42, Nicholls 16 | Box score |
| 09-10-22 | Carbondale, Ill. | Southeast Missouri 34, Southern Ill. 31 | Box score |
| 09-03-22 | Ames, Iowa | Iowa State 42, Southeast Missouri 10 | Box score |