| Date | Location | Result | |
| 11-20-21 | Cape Girardeau, Mo. | Southeast Missouri 31, UT Martin 14 | Box score |
| 11-13-21 | Murray, Ky. | Murray St. 28, Southeast Missouri 10 | Box score |
| 10-30-21 | Cape Girardeau, Mo. | Southeast Missouri 38, Eastern Illinois 15 | Box score |
| 10-23-21 | Martin, Tenn. | UT Martin 38, Southeast Missouri 30 | Box score |
| 10-16-21 | Cape Girardeau, Mo. | Murray State 32, Southeast Missouri 31 | Box score |
| 10-09-21 | Clarksville, Tenn. | Southeast Missouri 30, Austin Peay 14 | Box score |
| 10-02-21 | Cookeville, Tenn. | Tennessee Tech 28, Southeast Missouri 17 | Box score |
| 09-25-21 | Cape Girardeau, Mo. | Southeast Missouri 47, Tennessee State 14 | Box score |
| 09-18-21 | Columbia, Mo. | Missouri 59, Southeast Missouri 28 | Box score |
| 09-11-21 | Huntsville, Texas | Sam Houston 52, Southeast Missouri 14 | Box score |
| 09-02-21 | Cape Girardeau, Mo. | Southern Illinois 47, Southeast Missouri 21 | Box score |