| Date | Location | Result | |
| 12-04-10 | Cheney, Wash. | Eastern Washington 37, Southeast Missouri 17 | Box score |
| 11-13-10 | Jacksonville, Ala. | Jacksonville State 29, Southeast Missouri 27 | Box score |
| 11-06-10 | Cape Girardeau, Mo. | Southeast Missouri 40, Southwest Baptist 14 | Box score |
| 10-30-10 | Cape Girardeau, Mo. | Southeast Missouri 24, UT Martin 17 | Box score |
| 10-23-10 | Cape Girardeau, Mo. | Southeast Missouri 40, Eastern Kentucky 21 | Box score |
| 10-16-10 | Clarksville, Tenn. | Southeast Missouri 41, Austin Peay 24 | Box score |
| 10-09-10 | Cape Girardeau, Mo. | Southeast Missouri 19, Tennessee State 17 | Box score |
| 10-02-10 | Charleston, Ill. | Southeast Missouri 28, Eastern Illinois 13 | Box score |
| 09-25-10 | Cape Girardeau, Mo. | Southeast Missouri 23, Tennessee Tech 21 | Box score |
| 09-18-10 | Carbondale, Ill. | Southeast Missouri 24, Southern Illinois 21 | Box score |
| 09-11-10 | Murray, Ky. | Southeast Missouri 30, Murray State 17 | Box score |
| 09-02-10 | Muncie, Ind. | Ball State 27, Southeast Missouri 10 | Box score |