| Date | Location | Result | |
| 06-04-22 | Louisville, Ky. | Oregon 18, SE Missouri State 6 | Box score |
| 06-03-22 | Louisville, Ky. | Louisville 7, SE Missouri State 2 | Box score |
| 05-28-22 | Lexington, Ky. | Southeast Mo. 5, Belmont 4 | Box score |
| 05-27-22 | Lexington, Ky. | Southeast Mo. 5, Tennessee Tech 2 | Box score |
| 05-27-22 | Lexington, Ky. | Southeast Mo. 14, SIUE 6 | Box score |
| 05-26-22 | Lexington, Ky. | Tennessee Tech 11, Southeast Mo. 10 | Box score |
| 05-21-22 | Charleston, Ill. | Eastern Illinois 5, Southeast Missouri 1 | Box score |
| 05-20-22 | Charleston, Ill. | Eastern Illinois 7, Southeast Missouri 5 | Box score |
| 05-20-22 | Charleston, Ill. | Southeast Missouri 6, Eastern Illinois 4 | Box score |
| 05-15-22 | Cape Girardeau, Mo. | Southeast Missouri 15, Tennessee-Martin 2 | Box score |
| 05-14-22 | Cape Girardeau, Mo. | Southeast Missouri 7, Tennessee-Martin 6 | Box score |
| 05-13-22 | Cape Girardeau, Mo. | Tennessee-Martin 10, Southeast Missouri 3 | Box score |
| 05-10-22 | Cape Girardeau, Mo. | Southeast Missouri 8, Missouri State 7 | Box score |
| 05-08-22 | Stillwater, Okla. | Oklahoma State 15, SE Missouri State 3 | Box score |
| 05-07-22 | Stillwater, Okla. | Oklahoma State 11, SE Missouri State 6 | Box score |
| 05-06-22 | Stillwater, Okla. | Oklahoma State 4, SE Missouri State 0 | Box score |
| 05-03-22 | Columbia, Mo. | Mizzou 9, SEMO 3 | Box score |
| 05-01-22 | Nashville, Tenn. | Southeast Missouri 11, Belmont 4 | Box score |
| 04-30-22 | Nashville, Tenn. | Belmont 5, Southeast Missouri 3 | Box score |
| 04-29-22 | Nashville, Tenn. | Southeast Missouri 5, Belmont 4 | Box score |
| 04-26-22 | Carbondale, Ill. | Southern Illinois 7, Southeast Missouri 6 | Box score |
| 04-23-22 | Cape Girardeau, Mo. | Southeast Missouri 9, Morehead State 8 | Box score |
| 04-23-22 | Cape Girardeau, Mo. | Southeast Missouri 16, Morehead State 9 | Box score |
| 04-22-22 | Cape Girardeau, Mo. | Southeast Missouri 8, Morehead State 7 | Box score |
| 04-19-22 | Oxford, Miss. | Southeast Missouri 13, Ole Miss 3 | Box score |
| 04-16-22 | Cookeville, Tenn. | Tennessee Tech 7, Southeast Missouri 4 | Box score |
| 04-15-22 | Cookeville, Tenn. | Southeast Missouri 9, Tennessee Tech 4 | Box score |
| 04-14-22 | Cookeville, Tenn. | Tennessee Tech 10, Southeast Missouri 3 | Box score |
| 04-12-22 | Cape Girardeau, Mo. | Southern Illinois 3, Southeast Missouri 2 | Box score |
| 04-10-22 | Cape Girardeau, Mo. | Southeast Missouri 11, Murray State 10 | Box score |
| 04-09-22 | Cape Girardeau, Mo. | Southeast Missouri 8, Murray State 5 | Box score |
| 04-08-22 | Cape Girardeau, Mo. | Southeast Missouri 11, Murray State 2 | Box score |
| 04-05-22 | Cape Girardeau, Mo. | Southeast Missouri 8, Arkansas State 5 | Box score |
| 04-03-22 | Clarksville, Tenn. | Southeast Missouri 6, Austin Peay 5 | Box score |
| 04-02-22 | Clarksville, Tenn. | Austin Peay 8, Southeast Missouri 7 | Box score |
| 04-01-22 | Clarksville, Tenn. | Austin Peay 4, Southeast Missouri 3 | Box score |
| 03-29-22 | St. Louis, Mo. | Southeast Missouri 4, Saint Louis 1 | Box score |
| 03-27-22 | Cape Girardeau, Mo. | Southeast Missouri 5, SIUE 2 | Box score |
| 03-26-22 | Cape Girardeau, Mo. | Southeast Missouri 2, SIUE 1 | Box score |
| 03-25-22 | Cape Girardeau, Mo. | Southeast Missouri 2, SIUE 1 | Box score |
| 03-20-22 | Springfield, Mo. | Missouri State 16, Southeast Missouri 5 | Box score |
| 03-19-22 | Springfield, Mo. | Missouri State 9, Southeast Missouri 3 | Box score |
| 03-19-22 | Springfield, Mo. | Southeast Missouri 6, Missouri State 3 | Box score |
| 03-16-22 | Terre Haute, Ind. | Indiana State 5, SEMO 4 | Box score |
| 03-15-22 | Terre Haute, Ind. | Indiana State 10, SEMO 1 | Box score |
| 03-13-22 | Cape Girardeau, Mo. | Southeast Missouri 10, Valparaiso 8 | Box score |
| 03-13-22 | Cape Girardeau, Mo. | Southeast Missouri 16, Valparaiso 6 | Box score |
| 03-12-22 | Cape Girardeau, Mo. | Southeast Missouri 9, Valparaiso 1 | Box score |
| 03-08-22 | Jonesboro, Ark. | Southeast Missouri 14, Arkansas State 6 | Box score |
| 03-05-22 | Cape Girardeau, Mo. | Southeast Missouri 12, Bradley 5 | Box score |
| 03-05-22 | Cape Girardeau, Mo. | Southeast Missouri 11, Bradley 8 | Box score |
| 03-04-22 | Cape Girardeau, Mo. | Southeast Missouri 16, Bradley 7 | Box score |
| 03-01-22 | Cape Girardeau, Mo. | Southeast Missouri 16, Saint Louis 5 | Box score |
| 02-27-22 | Cape Girardeau, Mo. | Southeast Missouri 12, Bellarmine 8 | Box score |
| 02-27-22 | Cape Girardeau, Mo. | Southeast Missouri 10, Bellarmine 2 | Box score |
| 02-26-22 | Cape Girardeau, Mo. | Southeast Missouri 8, Bellarmine 7 | Box score |
| 02-20-22 | Dallas, Texas | Dallas Baptist 13, SEMO 5 | Box score |
| 02-19-22 | Dallas, Texas | SEMO 6, Dallas Baptist 5 | Box score |
| 02-18-22 | Dallas, Texas | SEMO 7, Dallas Baptist 6 | Box score |