| Date | Location | Result | |
| 06-05-21 | Oxford, Miss. | Southern Miss 21, Southeast Missouri 0 | Box score |
| 06-04-21 | Oxford, Miss. | Ole Miss 6, Southeast Missouri 3 | Box score |
| 05-30-21 | Jackson, Tenn. | Southeast Missouri 10, Murray State 1 | Box score |
| 05-29-21 | Jackson, Tenn. | Murray State 10, Southeast Missouri 1 | Box score |
| 05-28-21 | Jackson, Tenn. | Southeast Missouri 6, Murray State 5 | Box score |
| 05-27-21 | Jackson, Tenn. | Southeast Missouri 11, Austin Peay 8 | Box score |
| 05-21-21 | Cape Girardeau, Mo. | UT Martin 9, Southeast Missouri 2 | Box score |
| 05-21-21 | Cape Girardeau, Mo. | Southeast Missouri 3, UT Martin 2 | Box score |
| 05-20-21 | Cape Girardeau, Mo. | Southeast Missouri 6, UT Martin 2 | Box score |
| 05-15-21 | Nashville, Tenn. | SEMO 8, Lipscomb 4 | Box score |
| 05-14-21 | Nashville, Tenn. | Lipscomb 3, SEMO 0 | Box score |
| 05-13-21 | Nashville, Tenn. | SEMO 3, Lipscomb 2 | Box score |
| 05-08-21 | Cape Girardeau, Mo. | Southeast Missouri 7, Eastern Kentucky 6 | Box score |
| 05-07-21 | Cape Girardeau, Mo. | Eastern Kentucky 8, Southeast Missouri 0 | Box score |
| 05-07-21 | Cape Girardeau, Mo. | Southeast Missouri 6, Eastern Kentucky 2 | Box score |
| 05-01-21 | Nashville, Tenn. | SEMO 5, Belmont 0 | Box score |
| 05-01-21 | Nashville, Tenn. | Belmont 4, SEMO 1 | Box score |
| 04-30-21 | Nashville, Tenn. | SEMO 12, Belmont 0 | Box score |
| 04-28-21 | Clarksville, Tenn. | Southeast Missouri 16, Austin Peay 3 | Box score |
| 04-17-21 | Cape Girardeau, Mo. | Southeast Missouri 7, Tennessee Tech 2 | Box score |
| 04-17-21 | Cape Girardeau, Mo. | Tennessee Tech 9, Southeast Missouri 1 | Box score |
| 04-16-21 | Cape Girardeau, Mo. | Southeast Missouri 7, Tennessee Tech 3 | Box score |
| 04-13-21 | Martin, Tenn. | Southeast Missouri 8, UT Martin 1 | Box score |
| 04-10-21 | Murray, Ky. | Murray State 11, Southeast Missouri 6 | Box score |
| 04-09-21 | Murray, Ky. | Southeast Missouri 12, Murray State 8 | Box score |
| 04-09-21 | Murray, Ky. | Southeast Missouri 8, Murray State 3 | Box score |
| 04-03-21 | Cape Girardeau, MO. | Southeast Missouri 8, Jacksonville State 3 | Box score |
| 04-03-21 | Cape Girardeau, Mo. | Jacksonville State 8, Southeast Missouri 4 | Box score |
| 04-02-21 | Cape Girardeau, Mo. | Southeast Missouri 6, Jacksonville State 5 | Box score |
| 03-30-21 | Cape Girardeau, Mo. | Missouri State 9, Southeast Missouri 8 | Box score |
| 03-27-21 | Charleston, Ill. | Eastern Illinois 8, Southeast Missouri 4 | Box score |
| 03-27-21 | Charleston, Ill. | Eastern Illinois 9, Southeast Missouri 2 | Box score |
| 03-26-21 | Charleston, Ill. | Southeast Missouri 3, Eastern Illinois 2 | Box score |
| 03-24-21 | Cape Girardeau, Mo. | Southern Illinois 21, Southeast Missouri 4 | Box score |
| 03-20-21 | Cape Girardeau, Mo. | Austin Peay 12, Southeast Missouri 11 | Box score |
| 03-20-21 | Cape Girardeau, Mo. | Southeast Missouri 6, Austin Peay 5 | Box score |
| 03-19-21 | Cape Girardeau, Mo. | Southeast Missouri 6, Austin Peay 3 | Box score |
| 03-16-21 | St. Louis, Mo. | Southeast Missouri 8, Saint Louis 6 | Box score |
| 03-13-21 | Edwardsville, Ill. | Southeast Mo. St. 6, SIUE 4 | Box score |
| 03-13-21 | Edwardsville, Ill. | Southeast Mo. St. 6, SIUE 3 | Box score |
| 03-12-21 | Edwardsville, Ill. | SIUE 6, Southeast Mo. St. 2 | Box score |
| 03-07-21 | Cape Girardeau, Mo. | Southeast Missouri 8, Illinois State 1 | Box score |
| 03-06-21 | Cape Girardeau, Mo. | Illinois State 13, Southeast Missouri 1 | Box score |
| 03-06-21 | Cape Girardeau, Mo. | Southeast Missouri 5, Illinois State 1 | Box score |
| 03-05-21 | Cape Girardeau, Mo. | Southeast Missouri 4, Illinois State 3 | Box score |
| 02-28-21 | Fayetteville, Ark. | Arkansas 11, SE Missouri State 4 | Box score |
| 02-27-21 | Fayetteville, Ark. | Arkansas 9, SE Missouri State 3 | Box score |
| 02-26-21 | Fayetteville, Ark. | Arkansas 7, SE Missouri State 3 | Box score |
| 02-25-21 | Fayetteville, Ark. | Arkansas 6, SE Missouri State 5 | Box score |
| 02-21-21 | Mobile, Ala. | Southeast Missouri 8, South Alabama 6 | Box score |
| 02-20-21 | Mobile, Ala. | South Alabama 6, Southeast Missouri 5 | Box score |
| 02-19-21 | Mobile, Ala. | Southeast Missouri 4, South Alabama 2 | Box score |