| Date | Location | Result | |
| 03/04/21 | Murray St. 67, Southeast Mo. St. 64 | Box score | |
| 02/27/21 | Edwardsville, IL | Southeast Mo. St. 63, SIUE 52 | Box score |
| 02/25/21 | Charleston, IL | Eastern Ill. 65, Southeast Mo. St. 57 | Box score |
| 02-20-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 61, Morehead State 52 | Box score |
| 02-18-21 | Show Me Center -- Cape Girardeau, Mo. | Eastern Kentucky 82, Southeast Missouri 72 | Box score |
| 02/13/21 | Clarksville, TN | Southeast Mo. St. 73, Austin Peay 68 (OT) | Box score |
| 02/12/21 | Murray, KY | Murray St. 81, Southeast Mo. St. 79 | Box score |
| 02/09/21 | Nashville, TN | Southeast Mo. St. 70, Belmont 66 | Box score |
| 02-06-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 62, Jacksonville State 54 | Box score |
| 02-04-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 59, Tennessee Tech 55 | Box score |
| 02/01/21 | Martin, TN | UT Martin 80, Southeast Mo. St. 70 | Box score |
| 01-30-21 | Show Me Center -- Cape Girardeau, Mo. | Eastern Illinois 51, Southeast Missouri 49 | Box score |
| 01-28-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 77, SIUE 62 | Box score |
| 01/23/21 | Richmond, Ky. (McBrayer Arena) | Southeast Missouri 61, Eastern Kentucky 55 | Box score |
| 1/21/21 | Morehead, Ky. | Morehead State 58, Southeast Missouri 57 | Box score |
| 01-16-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 74, Austin Peay 61 | Box score |
| 01-14-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 69, Murray State 53 | Box score |
| 01/09/21 | Nashville, TN | Southeast Mo. St. 64, Tennessee St. 45 | Box score |
| 01-02-21 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 84, Tennessee State 50 | Box score |
| 12/30/20 | Cookeville, TN | Southeast Mo. St. 79, Tennessee Tech 70 | Box score |
| 12-18-20 | Show Me Center -- Cape Girardeau, Mo. | UT Martin 61, Southeast Missouri 58 | Box score |
| 12-13-20 | Carbondale, Ill. | Southern Ill. 67, Southeast Missouri 51 | Box score |
| 12-11-20 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 67, Western Illinois 57 | Box score |
| 12-06-20 | Show Me Center -- Cape Girardeau, Mo. | Eastern Michigan 63, Southeast Missouri 49 | Box score |
| 12-01-20 | Show Me Center -- Cape Girardeau, Mo. | Southeast Missouri 75, Eutectics 44 | Box score |
| 11-25-20 | Show Me Center -- Cape Girardeau, Mo. | #5 Louisville 74, Southeast Missouri 53 | Box score |